LAURA BROWN. Page earned his bachelor’s degree at Swarthmore College and his MD at Harvard Medical School. http://dx.doi.org/10.7554/eLife.19993.013. In mammals, the germline is set aside early in development for the later production of the gametes, either eggs or sperm. The HDL receptor scavenger receptor, class B type I (SR-BI) controls the structure and fate of plasma HDL. The Sabatini lab has broad interests in the regulation of growth and metabolism in mammals. We have identified many of the protein components of the mTOR pathway and are beginning to understand their functions at the cell and organismal level and in diseases such as cancer and diabetes as well as in aging. Our work has focused in part on a cellular network called the mTOR pathway, a … All ΔΔCt values were normalized to Actb qPCR results and displayed as fold change over IgG RIP-qPCR. David C. Page examines the genetic differences between males and females — and how these play out in disease, development, and evolution. Expression of Meioc is measured in fragments per kilobase per million reads (FPKM). Germ cell licensing has been considered to be a cell-autonomous... We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. We must challenge ourselves to address how our scientific research institutions can help address the clear racial divide. We show that single-c... Susceptibility to cancer is heritable, but much of this heritability remains unexplained. David Page, professor of biology at MIT, was named interim director of the Whitehead Institute for Biomedical Research in December. While this has been a conversation that we have had from time to time, we have not sustained that effort, and our leadership ranks continue to be predominantly white and male. Corrigendum: Parallel evolution of male germline epigenetic poising and somatic development in animals, Parallel evolution of male germline epigenetic poising and somatic development in animals, A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends, The Biology and Evolution of Mammalian Y Chromosomes, A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary, TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse, Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals, Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis, Proceedings From the Turner Resource Network Symposium: The Crossroads of Health Care Research and Health Care Delivery, Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling, Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes, Excess cholesterol induces mouse egg activation and may cause female infertility, The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice, Poised chromatin in the mammalian germ line, Identification of a novel, ancient family of germ cell enriched proteins, Retinoic Acid Activates Two Pathways Required for Meiosis in Mice, A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response, Corrigendum: Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators, No bull: Upholding community standards in public sharing of biological datasets, A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis, Independent specialization of the human and mouse X chromosomes for the male germline, Department of Molecular Virology, Immunology and Medical Genetics. Rabbit anti-MEIOC antibodies were generated to a peptide corresponding to the terminal 20 amino acids of mouse MEIOC (CHESINSSNPMNQRGETSKH). We searched for homologs of mouse YTHDC2 (NP_001156485) by querying the RefSeq protein database by blastp. Samples A are IgG IP from wild-type lysates; samples B are MEIOC IP from wild-type lysates; and samples C are MEIOC IP from Meioc-deficient lysates. In multicellular organisms, germ cells carry the hereditary material from one generation to the next.